| La Crosse to Des Plaines (Illinois) | 208.78 mi (336.00 km) |
| La Crosse to Desert Hot Springs (California) | 1,514.28 mi (2,437.00 km) |
| La Crosse to DeSoto (Texas) | 833.22 mi (1,340.93 km) |
| La Crosse to Destin (Florida) | 963.72 mi (1,550.95 km) |
| La Crosse to Destrehan (Louisiana) | 958.90 mi (1,543.20 km) |
| La Crosse to Detroit (Michigan) | 421.57 mi (678.45 km) |
| La Crosse to Diamond Bar (California) | 1,573.17 mi (2,531.77 km) |
| La Crosse to Diamond Springs (California) | 1,569.41 mi (2,525.72 km) |
| La Crosse to Dickinson (North Dakota) | 599.48 mi (964.77 km) |
| La Crosse to Dickinson (Texas) | 1,014.99 mi (1,633.46 km) |
| La Crosse to Dickson (Tennessee) | 573.68 mi (923.25 km) |
| La Crosse to Difficult Run (Virginia) | 794.71 mi (1,278.96 km) |
| La Crosse to Dinuba (California) | 1,560.82 mi (2,511.90 km) |
| La Crosse to Discovery Bay (California) | 1,628.79 mi (2,621.28 km) |
| La Crosse to Dix Hills (New York) | 935.53 mi (1,505.59 km) |
