| Knowsley to Southern Pines (North Carolina) | 3,787.67 mi (6,095.66 km) |
| Knowsley to Southfield (Michigan) | 3,592.89 mi (5,782.19 km) |
| Knowsley to Southgate (Michigan) | 3,603.35 mi (5,799.02 km) |
| Knowsley to Southlake (Texas) | 4,591.36 mi (7,389.08 km) |
| Knowsley to Spanaway (Washington) | 4,639.37 mi (7,466.35 km) |
| Knowsley to Spanish Fork (Utah) | 4,714.38 mi (7,587.06 km) |
| Knowsley to Spanish Lake (Missouri) | 4,031.98 mi (6,488.84 km) |
| Knowsley to Spanish Springs (Nevada) | 4,988.02 mi (8,027.44 km) |
| Knowsley to Sparks (Nevada) | 4,994.17 mi (8,037.35 km) |
| Knowsley to Spartanburg (South Carolina) | 3,900.38 mi (6,277.06 km) |
| Knowsley to Spearfish (South Dakota) | 4,226.65 mi (6,802.14 km) |
| Knowsley to Speedway (Indiana) | 3,832.96 mi (6,168.56 km) |
| Knowsley to Spencer (Iowa) | 3,998.09 mi (6,434.30 km) |
| Knowsley to Spokane (Washington) | 4,471.81 mi (7,196.69 km) |
| Knowsley to Spokane Valley (Washington) | 4,466.53 mi (7,188.18 km) |
