| Key West to Indianapolis (Indiana) | 1,081.32 mi (1,740.21 km) |
| Key West to Indianola (Iowa) | 1,343.89 mi (2,162.78 km) |
| Key West to Indio (California) | 2,162.18 mi (3,479.69 km) |
| Key West to Inglewood (California) | 2,284.22 mi (3,676.09 km) |
| Key West to Inkster (Michigan) | 1,228.12 mi (1,976.47 km) |
| Key West to Inver Grove Heights (Minnesota) | 1,536.05 mi (2,472.04 km) |
| Key West to Inwood (New York) | 1,202.49 mi (1,935.22 km) |
| Key West to Iona (Florida) | 135.34 mi (217.80 km) |
| Key West to Ionia (Michigan) | 1,285.94 mi (2,069.52 km) |
| Key West to Iowa City (Iowa) | 1,306.72 mi (2,102.97 km) |
| Key West to Irmo (South Carolina) | 659.91 mi (1,062.03 km) |
| Key West to Irondale (Alabama) | 686.71 mi (1,105.15 km) |
| Key West to Ironton (Ohio) | 966.54 mi (1,555.50 km) |
| Key West to Irvine (California) | 2,249.45 mi (3,620.14 km) |
| Key West to Irving (Texas) | 1,082.61 mi (1,742.29 km) |
