| Key West to Friendly (Maryland) | 1,020.43 mi (1,642.23 km) |
| Key West to Friendswood (Texas) | 893.07 mi (1,437.26 km) |
| Key West to Frisco (Texas) | 1,084.92 mi (1,746.01 km) |
| Key West to Front Royal (Virginia) | 1,014.27 mi (1,632.31 km) |
| Key West to Fruit Cove (Florida) | 382.42 mi (615.44 km) |
| Key West to Fruita (Colorado) | 1,864.32 mi (3,000.33 km) |
| Key West to Fruitville (Florida) | 195.95 mi (315.36 km) |
| Key West to Fuller Heights (Florida) | 232.45 mi (374.09 km) |
| Key West to Fullerton (California) | 2,259.91 mi (3,636.98 km) |
| Key West to Fullerton (Pennsylvania) | 1,168.14 mi (1,879.94 km) |
| Key West to Fulshear (Texas) | 935.92 mi (1,506.22 km) |
| Key West to Fulton (Missouri) | 1,152.52 mi (1,854.81 km) |
| Key West to Fulton (New York) | 1,330.88 mi (2,141.84 km) |
| Key West to Fuquay-Varina (North Carolina) | 782.86 mi (1,259.90 km) |
| Key West to Gadsden (Alabama) | 700.54 mi (1,127.40 km) |
