| Key West to Enterprise (Nevada) | 2,133.51 mi (3,433.56 km) |
| Key West to Enumclaw (Washington) | 2,696.09 mi (4,338.93 km) |
| Key West to Ephrata (Pennsylvania) | 1,126.70 mi (1,813.25 km) |
| Key West to Erie (Colorado) | 1,719.56 mi (2,767.36 km) |
| Key West to Erie (Pennsylvania) | 1,216.67 mi (1,958.04 km) |
| Key West to Erlanger (Kentucky) | 1,011.56 mi (1,627.94 km) |
| Key West to Escanaba (Michigan) | 1,493.22 mi (2,403.10 km) |
| Key West to Escondido (California) | 2,205.04 mi (3,548.67 km) |
| Key West to Española (New Mexico) | 1,644.09 mi (2,645.90 km) |
| Key West to Essex (Maryland) | 1,064.66 mi (1,713.40 km) |
| Key West to Essex Junction (Vermont) | 1,460.32 mi (2,350.15 km) |
| Key West to Estelle (Louisiana) | 627.99 mi (1,010.65 km) |
| Key West to Estero (Florida) | 128.75 mi (207.21 km) |
| Key West to Euclid (Ohio) | 1,176.48 mi (1,893.37 km) |
| Key West to Eufaula (Alabama) | 547.41 mi (880.98 km) |
