| Key West to Clarksdale (Mississippi) | 849.36 mi (1,366.91 km) |
| Key West to Clarkston (Georgia) | 655.91 mi (1,055.59 km) |
| Key West to Clarksville (Indiana) | 978.94 mi (1,575.46 km) |
| Key West to Clarksville (Tennessee) | 892.60 mi (1,436.50 km) |
| Key West to Clawson (Michigan) | 1,244.25 mi (2,002.42 km) |
| Key West to Clay (Alabama) | 694.76 mi (1,118.10 km) |
| Key West to Clayton (California) | 2,522.07 mi (4,058.88 km) |
| Key West to Clayton (Missouri) | 1,094.02 mi (1,760.65 km) |
| Key West to Clayton (North Carolina) | 791.80 mi (1,274.28 km) |
| Key West to Clayton (Ohio) | 1,067.78 mi (1,718.43 km) |
| Key West to Clearfield (Utah) | 2,078.29 mi (3,344.68 km) |
| Key West to Clearlake (California) | 2,571.78 mi (4,138.87 km) |
| Key West to Clearwater (Florida) | 243.70 mi (392.19 km) |
| Key West to Cleburne (Texas) | 1,090.07 mi (1,754.30 km) |
| Key West to Clemmons (North Carolina) | 796.65 mi (1,282.08 km) |
