| Key West to Sesena | 4,539.57 mi (7,305.73 km) |
| Key West to Sestao | 4,528.54 mi (7,287.97 km) |
| Key West to Sevilla | 4,461.65 mi (7,180.34 km) |
| Key West to Sevilla La Nueva | 4,518.94 mi (7,272.53 km) |
| Key West to Silla | 4,721.40 mi (7,598.36 km) |
| Key West to Silleda | 4,275.76 mi (6,881.16 km) |
| Key West to Sitges | 4,800.88 mi (7,726.27 km) |
| Key West to Socuellamos | 4,598.92 mi (7,401.24 km) |
| Key West to Soller | 4,873.65 mi (7,843.38 km) |
| Key West to Solsona | 4,773.01 mi (7,681.41 km) |
| Key West to Son Servera | 4,910.16 mi (7,902.14 km) |
| Key West to Sonseca | 4,532.57 mi (7,294.46 km) |
| Key West to Sopelana | 4,528.87 mi (7,288.51 km) |
| Key West to Soria | 4,577.51 mi (7,366.79 km) |
| Key West to Suances | 4,475.43 mi (7,202.52 km) |
