| Key West to Santa Ursula | 3,996.32 mi (6,431.45 km) |
| Key West to Santander | 4,487.12 mi (7,221.32 km) |
| Key West to Santany | 4,903.59 mi (7,891.57 km) |
| Key West to Santiago de Compostela | 4,258.36 mi (6,853.17 km) |
| Key West to Santiago del Teide | 3,979.11 mi (6,403.76 km) |
| Key West to Santiponce | 4,455.88 mi (7,171.05 km) |
| Key West to Santomera | 4,710.90 mi (7,581.46 km) |
| Key West to Santona | 4,504.51 mi (7,249.31 km) |
| Key West to Santurce-Antiguo | 4,527.00 mi (7,285.50 km) |
| Key West to Sarria | 4,315.83 mi (6,945.66 km) |
| Key West to Sauzal | 3,998.82 mi (6,435.47 km) |
| Key West to Sedavi | 4,721.57 mi (7,598.64 km) |
| Key West to Segorbe | 4,708.83 mi (7,578.12 km) |
| Key West to Segovia | 4,505.70 mi (7,251.22 km) |
| Key West to Senmanat | 4,810.66 mi (7,742.00 km) |
