| James Island to Yonkers (New York) | 658.83 mi (1,060.29 km) |
| James Island to Yorba Linda (California) | 2,173.50 mi (3,497.91 km) |
| James Island to York (Pennsylvania) | 530.36 mi (853.54 km) |
| James Island to Yorktown (Indiana) | 600.27 mi (966.04 km) |
| James Island to Yorkville (Illinois) | 773.31 mi (1,244.52 km) |
| James Island to Youngstown (Ohio) | 579.21 mi (932.15 km) |
| James Island to Youngsville (Louisiana) | 733.49 mi (1,180.45 km) |
| James Island to Ypsilanti (Michigan) | 687.10 mi (1,105.78 km) |
| James Island to Yuba City (California) | 2,353.21 mi (3,787.13 km) |
| James Island to Yucaipa (California) | 2,130.74 mi (3,429.09 km) |
| James Island to Yucca Valley (California) | 2,094.67 mi (3,371.04 km) |
| James Island to Yukon (Oklahoma) | 1,035.95 mi (1,667.20 km) |
| James Island to Yulee (Florida) | 173.85 mi (279.78 km) |
| James Island to Yuma (Arizona) | 2,003.92 mi (3,225.00 km) |
| James Island to Zachary (Louisiana) | 674.79 mi (1,085.96 km) |
