| James Island to University Place (Washington) | 2,430.29 mi (3,911.18 km) |
| James Island to Upland (California) | 2,164.89 mi (3,484.05 km) |
| James Island to Upper Arlington (Ohio) | 532.97 mi (857.74 km) |
| James Island to Upper Grand Lagoon (Florida) | 385.09 mi (619.74 km) |
| James Island to Upper Montclair (New Jersey) | 643.57 mi (1,035.73 km) |
| James Island to Urbana (Illinois) | 685.25 mi (1,102.80 km) |
| James Island to Urbana (Maryland) | 477.96 mi (769.21 km) |
| James Island to Urbana (Ohio) | 551.67 mi (887.83 km) |
| James Island to Urbandale (Iowa) | 977.11 mi (1,572.50 km) |
| James Island to Utica (New York) | 760.23 mi (1,223.47 km) |
| James Island to Uvalde (Texas) | 1,198.24 mi (1,928.38 km) |
| James Island to Vacaville (California) | 2,373.75 mi (3,820.18 km) |
| James Island to Vadnais Heights (Minnesota) | 1,103.25 mi (1,775.51 km) |
| James Island to Vail (Arizona) | 1,788.91 mi (2,878.97 km) |
| James Island to Valdosta (Georgia) | 235.40 mi (378.84 km) |
