| James Island to Superior (Colorado) | 1,483.13 mi (2,386.86 km) |
| James Island to Superior (Wisconsin) | 1,157.46 mi (1,862.75 km) |
| James Island to Surprise (Arizona) | 1,872.86 mi (3,014.08 km) |
| James Island to Susanville (California) | 2,297.11 mi (3,696.85 km) |
| James Island to Sussex (Wisconsin) | 847.53 mi (1,363.97 km) |
| James Island to Suwanee (Georgia) | 254.93 mi (410.27 km) |
| James Island to Swansea (Illinois) | 691.87 mi (1,113.46 km) |
| James Island to Sweetwater (Florida) | 481.39 mi (774.72 km) |
| James Island to Sweetwater (Texas) | 1,189.76 mi (1,914.73 km) |
| James Island to Sycamore (Illinois) | 798.96 mi (1,285.80 km) |
| James Island to Sylacauga (Alabama) | 367.68 mi (591.73 km) |
| James Island to Sylvania (Ohio) | 653.67 mi (1,051.98 km) |
| James Island to Syosset (New York) | 661.83 mi (1,065.11 km) |
| James Island to Syracuse (New York) | 741.28 mi (1,192.98 km) |
| James Island to Syracuse (Utah) | 1,854.28 mi (2,984.18 km) |
