| James Island to Storm Lake (Iowa) | 1,076.14 mi (1,731.88 km) |
| James Island to Storrs (Connecticut) | 755.34 mi (1,215.60 km) |
| James Island to Stoughton (Wisconsin) | 866.07 mi (1,393.81 km) |
| James Island to Stow (Ohio) | 589.01 mi (947.93 km) |
| James Island to Streamwood (Illinois) | 784.13 mi (1,261.93 km) |
| James Island to Streator (Illinois) | 758.78 mi (1,221.14 km) |
| James Island to Streetsboro (Ohio) | 592.67 mi (953.81 km) |
| James Island to Strongsville (Ohio) | 601.72 mi (968.38 km) |
| James Island to Stuart (Florida) | 383.17 mi (616.65 km) |
| James Island to Stuarts Draft (Virginia) | 368.58 mi (593.18 km) |
| James Island to Sturgis (Michigan) | 694.55 mi (1,117.78 km) |
| James Island to Suamico (Wisconsin) | 930.65 mi (1,497.73 km) |
| James Island to Sudley (Virginia) | 440.00 mi (708.11 km) |
| James Island to Suffern (New York) | 661.16 mi (1,064.03 km) |
| James Island to Suffolk (Virginia) | 331.58 mi (533.62 km) |
