| James Island to St. Simons (Georgia) | 137.01 mi (220.50 km) |
| James Island to Stafford (Texas) | 947.33 mi (1,524.58 km) |
| James Island to Stallings (North Carolina) | 169.11 mi (272.16 km) |
| James Island to Stamford (Connecticut) | 676.70 mi (1,089.05 km) |
| James Island to Stanford (California) | 2,389.59 mi (3,845.68 km) |
| James Island to Stanton (California) | 2,187.03 mi (3,519.68 km) |
| James Island to Star (Idaho) | 2,103.44 mi (3,385.16 km) |
| James Island to Starkville (Mississippi) | 516.86 mi (831.81 km) |
| James Island to State College (Pennsylvania) | 568.35 mi (914.67 km) |
| James Island to Staten Island (New York) | 629.73 mi (1,013.45 km) |
| James Island to Statesboro (Georgia) | 108.83 mi (175.14 km) |
| James Island to Statesville (North Carolina) | 217.27 mi (349.67 km) |
| James Island to Staunton (Virginia) | 378.00 mi (608.34 km) |
| James Island to Steamboat Springs (Colorado) | 1,576.72 mi (2,537.49 km) |
| James Island to Steiner Ranch (Texas) | 1,068.55 mi (1,719.67 km) |
