| James Island to Southern Pines (North Carolina) | 172.54 mi (277.68 km) |
| James Island to Southfield (Michigan) | 697.01 mi (1,121.73 km) |
| James Island to Southgate (Michigan) | 678.20 mi (1,091.45 km) |
| James Island to Southlake (Texas) | 998.06 mi (1,606.23 km) |
| James Island to Spanaway (Washington) | 2,423.37 mi (3,900.04 km) |
| James Island to Spanish Fork (Utah) | 1,823.79 mi (2,935.11 km) |
| James Island to Spanish Lake (Missouri) | 710.81 mi (1,143.94 km) |
| James Island to Spanish Springs (Nevada) | 2,247.26 mi (3,616.61 km) |
| James Island to Sparks (Nevada) | 2,249.79 mi (3,620.69 km) |
| James Island to Spartanburg (South Carolina) | 190.46 mi (306.52 km) |
| James Island to Spearfish (South Dakota) | 1,514.87 mi (2,437.94 km) |
| James Island to Speedway (Indiana) | 600.76 mi (966.82 km) |
| James Island to Spencer (Iowa) | 1,094.47 mi (1,761.38 km) |
| James Island to Spokane (Washington) | 2,202.29 mi (3,544.24 km) |
| James Island to Spokane Valley (Washington) | 2,193.26 mi (3,529.72 km) |
