| James Island to Smyrna (Delaware) | 513.56 mi (826.49 km) |
| James Island to Smyrna (Georgia) | 275.56 mi (443.47 km) |
| James Island to Smyrna (Tennessee) | 436.98 mi (703.25 km) |
| James Island to Snellville (Georgia) | 247.15 mi (397.75 km) |
| James Island to Snoqualmie (Washington) | 2,401.22 mi (3,864.39 km) |
| James Island to Snyder (Texas) | 1,217.04 mi (1,958.64 km) |
| James Island to Socastee (South Carolina) | 84.97 mi (136.75 km) |
| James Island to Socorro (Texas) | 1,537.02 mi (2,473.59 km) |
| James Island to Soddy-Daisy (Tennessee) | 346.72 mi (557.99 km) |
| James Island to Solana Beach (California) | 2,154.23 mi (3,466.89 km) |
| James Island to Soledad (California) | 2,350.95 mi (3,783.49 km) |
| James Island to Solon (Ohio) | 603.41 mi (971.09 km) |
| James Island to Somers Point (New Jersey) | 543.42 mi (874.55 km) |
| James Island to Somerset (Kentucky) | 400.28 mi (644.18 km) |
| James Island to Somerset (New Jersey) | 615.62 mi (990.75 km) |
