| James Island to Silver Firs (Washington) | 2,419.31 mi (3,893.51 km) |
| James Island to Silver Spring (Maryland) | 462.78 mi (744.76 km) |
| James Island to Silver Springs Shores (Florida) | 278.88 mi (448.82 km) |
| James Island to Silverdale (Washington) | 2,441.46 mi (3,929.15 km) |
| James Island to Silverton (Oregon) | 2,422.74 mi (3,899.02 km) |
| James Island to Simi Valley (California) | 2,224.97 mi (3,580.74 km) |
| James Island to Simpsonville (South Carolina) | 191.57 mi (308.30 km) |
| James Island to Sioux City (Iowa) | 1,121.56 mi (1,804.97 km) |
| James Island to Sioux Falls (South Dakota) | 1,175.01 mi (1,891.00 km) |
| James Island to Skokie (Illinois) | 771.45 mi (1,241.53 km) |
| James Island to Sleepy Hollow (New York) | 667.29 mi (1,073.89 km) |
| James Island to Slidell (Louisiana) | 603.68 mi (971.53 km) |
| James Island to Smithfield (North Carolina) | 212.38 mi (341.80 km) |
| James Island to Smithfield (Utah) | 1,849.52 mi (2,976.51 km) |
| James Island to Smithville (Missouri) | 936.21 mi (1,506.69 km) |
