| James Island to Seymour (Tennessee) | 307.97 mi (495.63 km) |
| James Island to Shady Hills (Florida) | 337.03 mi (542.39 km) |
| James Island to Shafter (California) | 2,239.39 mi (3,603.95 km) |
| James Island to Shaker Heights (Ohio) | 610.26 mi (982.12 km) |
| James Island to Shakopee (Minnesota) | 1,103.30 mi (1,775.59 km) |
| James Island to Sharon (Pennsylvania) | 588.01 mi (946.32 km) |
| James Island to Sharonville (Ohio) | 516.53 mi (831.27 km) |
| James Island to Shasta Lake (California) | 2,389.68 mi (3,845.82 km) |
| James Island to Shawnee (Kansas) | 937.06 mi (1,508.05 km) |
| James Island to Shawnee (Oklahoma) | 990.05 mi (1,593.33 km) |
| James Island to Sheboygan (Wisconsin) | 869.08 mi (1,398.66 km) |
| James Island to Shelby (North Carolina) | 199.05 mi (320.34 km) |
| James Island to Shelbyville (Indiana) | 571.47 mi (919.69 km) |
| James Island to Shelbyville (Kentucky) | 480.96 mi (774.03 km) |
| James Island to Shelbyville (Tennessee) | 418.46 mi (673.45 km) |
