| James Island to Security-Widefield (Colorado) | 1,445.02 mi (2,325.53 km) |
| James Island to Sedalia (Missouri) | 851.00 mi (1,369.55 km) |
| James Island to Sedro-Woolley (Washington) | 2,431.10 mi (3,912.48 km) |
| James Island to Seguin (Texas) | 1,086.39 mi (1,748.38 km) |
| James Island to Selden (New York) | 678.75 mi (1,092.35 km) |
| James Island to Selma (Alabama) | 413.56 mi (665.56 km) |
| James Island to Selma (California) | 2,254.56 mi (3,628.37 km) |
| James Island to Selma (Texas) | 1,106.40 mi (1,780.57 km) |
| James Island to Seminole (Florida) | 378.16 mi (608.59 km) |
| James Island to Seven Hills (Ohio) | 604.88 mi (973.46 km) |
| James Island to Seven Oaks (South Carolina) | 114.21 mi (183.81 km) |
| James Island to Severn (Maryland) | 477.90 mi (769.11 km) |
| James Island to Severna Park (Maryland) | 477.58 mi (768.59 km) |
| James Island to Sevierville (Tennessee) | 300.46 mi (483.54 km) |
| James Island to Seymour (Indiana) | 543.18 mi (874.17 km) |
