| James Island to Scottsboro (Alabama) | 375.10 mi (603.66 km) |
| James Island to Scottsdale (Arizona) | 1,839.36 mi (2,960.16 km) |
| James Island to Scranton (Pennsylvania) | 643.43 mi (1,035.51 km) |
| James Island to Seabrook (Maryland) | 464.78 mi (747.99 km) |
| James Island to Seabrook (Texas) | 917.33 mi (1,476.29 km) |
| James Island to Seaford (New York) | 653.73 mi (1,052.07 km) |
| James Island to Seagoville (Texas) | 964.62 mi (1,552.40 km) |
| James Island to Seal Beach (California) | 2,191.94 mi (3,527.59 km) |
| James Island to Searcy (Arkansas) | 697.11 mi (1,121.89 km) |
| James Island to Seaside (California) | 2,375.97 mi (3,823.75 km) |
| James Island to SeaTac (Washington) | 2,421.32 mi (3,896.73 km) |
| James Island to Seattle (Washington) | 2,424.49 mi (3,901.84 km) |
| James Island to Sebastian (Florida) | 343.75 mi (553.22 km) |
| James Island to Sebring (Florida) | 374.39 mi (602.53 km) |
| James Island to Secaucus (New Jersey) | 643.62 mi (1,035.80 km) |
