| James Island to Savannah (Georgia) | 87.42 mi (140.68 km) |
| James Island to Sayreville (New Jersey) | 617.97 mi (994.53 km) |
| James Island to Sayville (New York) | 670.72 mi (1,079.42 km) |
| James Island to Scaggsville (Maryland) | 474.40 mi (763.47 km) |
| James Island to Scarsdale (New York) | 663.90 mi (1,068.44 km) |
| James Island to Schaumburg (Illinois) | 781.72 mi (1,258.06 km) |
| James Island to Schenectady (New York) | 768.65 mi (1,237.03 km) |
| James Island to Schererville (Indiana) | 731.82 mi (1,177.76 km) |
| James Island to Schertz (Texas) | 1,103.36 mi (1,775.69 km) |
| James Island to Schiller Park (Illinois) | 771.10 mi (1,240.96 km) |
| James Island to Schofield Barracks (Hawaii) | 4,763.80 mi (7,666.59 km) |
| James Island to Scotchtown (New York) | 677.15 mi (1,089.77 km) |
| James Island to Scottdale (Georgia) | 260.29 mi (418.90 km) |
| James Island to Scotts Valley (California) | 2,383.46 mi (3,835.81 km) |
| James Island to Scottsbluff (Nebraska) | 1,441.93 mi (2,320.57 km) |
