| James Island to Santa Rosa (California) | 2,413.29 mi (3,883.82 km) |
| James Island to Santaquin (Utah) | 1,830.88 mi (2,946.52 km) |
| James Island to Santee (California) | 2,140.34 mi (3,444.54 km) |
| James Island to Sapulpa (Oklahoma) | 947.74 mi (1,525.25 km) |
| James Island to Saraland (Alabama) | 496.54 mi (799.11 km) |
| James Island to Sarasota (Florida) | 404.04 mi (650.24 km) |
| James Island to Sarasota Springs (Florida) | 404.41 mi (650.84 km) |
| James Island to Saratoga (California) | 2,382.86 mi (3,834.84 km) |
| James Island to Saratoga Springs (New York) | 788.40 mi (1,268.81 km) |
| James Island to Saratoga Springs (Utah) | 1,839.98 mi (2,961.16 km) |
| James Island to Sartell (Minnesota) | 1,169.99 mi (1,882.91 km) |
| James Island to Satellite Beach (Florida) | 317.33 mi (510.69 km) |
| James Island to Sauk Rapids (Minnesota) | 1,166.69 mi (1,877.60 km) |
| James Island to Sault Ste. Marie (Michigan) | 978.23 mi (1,574.31 km) |
| James Island to Savage (Minnesota) | 1,098.34 mi (1,767.61 km) |
