| James Island to Orangevale (California) | 2,332.18 mi (3,753.28 km) |
| James Island to Orchards (Washington) | 2,415.58 mi (3,887.50 km) |
| James Island to Orcutt (California) | 2,313.20 mi (3,722.73 km) |
| James Island to Oregon (Ohio) | 645.24 mi (1,038.42 km) |
| James Island to Oregon (Wisconsin) | 871.46 mi (1,402.48 km) |
| James Island to Oregon City (Oregon) | 2,415.93 mi (3,888.06 km) |
| James Island to Orem (Utah) | 1,828.31 mi (2,942.38 km) |
| James Island to Orinda (California) | 2,387.58 mi (3,842.44 km) |
| James Island to Orland Park (Illinois) | 751.59 mi (1,209.56 km) |
| James Island to Orlando (Florida) | 305.70 mi (491.98 km) |
| James Island to Ormond Beach (Florida) | 247.22 mi (397.86 km) |
| James Island to Oro Valley (Arizona) | 1,800.65 mi (2,897.86 km) |
| James Island to Oroville (California) | 2,348.30 mi (3,779.23 km) |
| James Island to Oshkosh (Wisconsin) | 907.82 mi (1,460.99 km) |
| James Island to Oskaloosa (Iowa) | 915.07 mi (1,472.66 km) |
