| James Island to Olympia Heights (Florida) | 485.03 mi (780.58 km) |
| James Island to Omaha (Nebraska) | 1,063.91 mi (1,712.19 km) |
| James Island to On Top of the World Designated Place (Florida) | 286.76 mi (461.49 km) |
| James Island to Onalaska (Wisconsin) | 981.40 mi (1,579.41 km) |
| James Island to Oneida (New York) | 751.34 mi (1,209.16 km) |
| James Island to Oneonta (New York) | 722.28 mi (1,162.39 km) |
| James Island to Ontario (California) | 2,162.61 mi (3,480.39 km) |
| James Island to Ontario (Oregon) | 2,130.68 mi (3,428.99 km) |
| James Island to Opa-locka (Florida) | 472.68 mi (760.70 km) |
| James Island to Opelika (Alabama) | 316.16 mi (508.82 km) |
| James Island to Opelousas (Louisiana) | 730.01 mi (1,174.83 km) |
| James Island to Orange (California) | 2,177.25 mi (3,503.95 km) |
| James Island to Orange (Texas) | 833.94 mi (1,342.09 km) |
| James Island to Orange City (Florida) | 274.50 mi (441.77 km) |
| James Island to Orangeburg (South Carolina) | 74.98 mi (120.66 km) |
