| James Island to Isabela (Puerto Rico) | 1,268.47 mi (2,041.41 km) |
| James Island to Iselin (New Jersey) | 624.26 mi (1,004.65 km) |
| James Island to Isla Vista (California) | 2,286.24 mi (3,679.34 km) |
| James Island to Issaquah (Washington) | 2,410.86 mi (3,879.90 km) |
| James Island to Ithaca (New York) | 696.53 mi (1,120.96 km) |
| James Island to Ives Estates (Florida) | 468.14 mi (753.39 km) |
| James Island to Jackson (Michigan) | 700.76 mi (1,127.76 km) |
| James Island to Jackson (Mississippi) | 598.94 mi (963.90 km) |
| James Island to Jackson (Missouri) | 635.67 mi (1,023.01 km) |
| James Island to Jackson (Tennessee) | 546.66 mi (879.76 km) |
| James Island to Jackson (Wyoming) | 1,819.68 mi (2,928.49 km) |
| James Island to Jacksonville (Alabama) | 343.96 mi (553.55 km) |
| James Island to Jacksonville (Arkansas) | 714.92 mi (1,150.55 km) |
| James Island to Jacksonville (Florida) | 194.96 mi (313.76 km) |
| James Island to Jacksonville (Illinois) | 749.11 mi (1,205.58 km) |
