| James Island to Indianapolis (Indiana) | 596.54 mi (960.04 km) |
| James Island to Indianola (Iowa) | 957.12 mi (1,540.33 km) |
| James Island to Indio (California) | 2,087.82 mi (3,360.02 km) |
| James Island to Inglewood (California) | 2,205.27 mi (3,549.03 km) |
| James Island to Inkster (Michigan) | 685.66 mi (1,103.47 km) |
| James Island to Inver Grove Heights (Minnesota) | 1,091.24 mi (1,756.18 km) |
| James Island to Inwood (New York) | 643.43 mi (1,035.50 km) |
| James Island to Iona (Florida) | 446.49 mi (718.56 km) |
| James Island to Ionia (Michigan) | 760.65 mi (1,224.14 km) |
| James Island to Iowa City (Iowa) | 885.50 mi (1,425.07 km) |
| James Island to Irmo (South Carolina) | 119.00 mi (191.52 km) |
| James Island to Irondale (Alabama) | 392.77 mi (632.11 km) |
| James Island to Ironton (Ohio) | 428.98 mi (690.38 km) |
| James Island to Irvine (California) | 2,175.88 mi (3,501.74 km) |
| James Island to Irving (Texas) | 988.10 mi (1,590.20 km) |
