| Ithaca to Southern Pines (North Carolina) | 524.71 mi (844.43 km) |
| Ithaca to Southfield (Michigan) | 344.36 mi (554.19 km) |
| Ithaca to Southgate (Michigan) | 342.70 mi (551.52 km) |
| Ithaca to Southlake (Texas) | 1,300.25 mi (2,092.55 km) |
| Ithaca to Spanaway (Washington) | 2,242.38 mi (3,608.76 km) |
| Ithaca to Spanish Fork (Utah) | 1,818.58 mi (2,926.72 km) |
| Ithaca to Spanish Lake (Missouri) | 760.81 mi (1,224.40 km) |
| Ithaca to Spanish Springs (Nevada) | 2,233.15 mi (3,593.91 km) |
| Ithaca to Sparks (Nevada) | 2,237.40 mi (3,600.75 km) |
| Ithaca to Spartanburg (South Carolina) | 594.67 mi (957.04 km) |
| Ithaca to Spearfish (South Dakota) | 1,370.43 mi (2,205.49 km) |
| Ithaca to Speedway (Indiana) | 538.89 mi (867.26 km) |
| Ithaca to Spencer (Iowa) | 944.85 mi (1,520.58 km) |
| Ithaca to Spokane (Washington) | 2,005.91 mi (3,228.20 km) |
| Ithaca to Spokane Valley (Washington) | 1,996.74 mi (3,213.44 km) |
