| Ithaca to Enterprise (Nevada) | 2,100.77 mi (3,380.87 km) |
| Ithaca to Enumclaw (Washington) | 2,221.15 mi (3,574.60 km) |
| Ithaca to Ephrata (Pennsylvania) | 157.26 mi (253.08 km) |
| Ithaca to Erie (Colorado) | 1,484.79 mi (2,389.53 km) |
| Ithaca to Erie (Pennsylvania) | 183.88 mi (295.93 km) |
| Ithaca to Erlanger (Kentucky) | 484.88 mi (780.33 km) |
| Ithaca to Escanaba (Michigan) | 572.19 mi (920.84 km) |
| Ithaca to Escondido (California) | 2,282.84 mi (3,673.87 km) |
| Ithaca to Española (New Mexico) | 1,634.57 mi (2,630.59 km) |
| Ithaca to Essex (Maryland) | 217.12 mi (349.42 km) |
| Ithaca to Essex Junction (Vermont) | 221.02 mi (355.70 km) |
| Ithaca to Estelle (Louisiana) | 1,151.76 mi (1,853.58 km) |
| Ithaca to Estero (Florida) | 1,146.36 mi (1,844.88 km) |
| Ithaca to Euclid (Ohio) | 264.09 mi (425.02 km) |
| Ithaca to Eufaula (Alabama) | 868.59 mi (1,397.87 km) |
