| Issoudun to Southern Pines (North Carolina) | 4,124.57 mi (6,637.85 km) |
| Issoudun to Southfield (Michigan) | 3,983.10 mi (6,410.18 km) |
| Issoudun to Southgate (Michigan) | 3,992.00 mi (6,424.50 km) |
| Issoudun to Southlake (Texas) | 4,985.30 mi (8,023.07 km) |
| Issoudun to Spanaway (Washington) | 5,125.35 mi (8,248.45 km) |
| Issoudun to Spanish Fork (Utah) | 5,171.10 mi (8,322.09 km) |
| Issoudun to Spanish Lake (Missouri) | 4,426.55 mi (7,123.85 km) |
| Issoudun to Spanish Springs (Nevada) | 5,459.75 mi (8,786.62 km) |
| Issoudun to Sparks (Nevada) | 5,465.86 mi (8,796.45 km) |
| Issoudun to Spartanburg (South Carolina) | 4,246.19 mi (6,833.59 km) |
| Issoudun to Spearfish (South Dakota) | 4,677.73 mi (7,528.09 km) |
| Issoudun to Speedway (Indiana) | 4,219.32 mi (6,790.34 km) |
| Issoudun to Spencer (Iowa) | 4,424.65 mi (7,120.79 km) |
| Issoudun to Spokane (Washington) | 4,952.60 mi (7,970.44 km) |
| Issoudun to Spokane Valley (Washington) | 4,947.05 mi (7,961.51 km) |
