| Irvine to Yonkers (New York) | 3,191.31 mi (5,135.92 km) |
| Irvine to Yorba Linda (California) | 5,110.59 mi (8,224.70 km) |
| Irvine to York (Pennsylvania) | 3,347.16 mi (5,386.74 km) |
| Irvine to Yorktown (Indiana) | 3,665.43 mi (5,898.94 km) |
| Irvine to Yorkville (Illinois) | 3,699.58 mi (5,953.90 km) |
| Irvine to Youngstown (Ohio) | 3,440.19 mi (5,536.45 km) |
| Irvine to Youngsville (Louisiana) | 4,429.91 mi (7,129.24 km) |
| Irvine to Ypsilanti (Michigan) | 3,495.24 mi (5,625.05 km) |
| Irvine to Yuba City (California) | 4,919.65 mi (7,917.42 km) |
| Irvine to Yucaipa (California) | 5,079.55 mi (8,174.75 km) |
| Irvine to Yucca Valley (California) | 5,054.93 mi (8,135.13 km) |
| Irvine to Yukon (Oklahoma) | 4,350.07 mi (7,000.76 km) |
| Irvine to Yulee (Florida) | 4,004.14 mi (6,444.03 km) |
| Irvine to Yuma (Arizona) | 5,083.29 mi (8,180.77 km) |
| Irvine to Zachary (Louisiana) | 4,368.15 mi (7,029.86 km) |
