| Irvine to University Place (Washington) | 4,474.92 mi (7,201.68 km) |
| Irvine to Upland (California) | 5,093.86 mi (8,197.77 km) |
| Irvine to Upper Arlington (Ohio) | 3,582.71 mi (5,765.81 km) |
| Irvine to Upper Grand Lagoon (Florida) | 4,189.05 mi (6,741.62 km) |
| Irvine to Upper Montclair (New Jersey) | 3,208.90 mi (5,164.23 km) |
| Irvine to Urbana (Illinois) | 3,767.35 mi (6,062.96 km) |
| Irvine to Urbana (Maryland) | 3,401.20 mi (5,473.71 km) |
| Irvine to Urbana (Ohio) | 3,604.12 mi (5,800.26 km) |
| Irvine to Urbandale (Iowa) | 3,889.93 mi (6,260.24 km) |
| Irvine to Utica (New York) | 3,142.83 mi (5,057.90 km) |
| Irvine to Uvalde (Texas) | 4,765.30 mi (7,669.01 km) |
| Irvine to Vacaville (California) | 4,974.58 mi (8,005.82 km) |
| Irvine to Vadnais Heights (Minnesota) | 3,694.59 mi (5,945.87 km) |
| Irvine to Vail (Arizona) | 4,989.81 mi (8,030.32 km) |
| Irvine to Valdosta (Georgia) | 4,058.68 mi (6,531.82 km) |
