| Irvine to Superior (Colorado) | 4,366.66 mi (7,027.46 km) |
| Irvine to Superior (Wisconsin) | 3,581.04 mi (5,763.13 km) |
| Irvine to Surprise (Arizona) | 4,953.40 mi (7,971.73 km) |
| Irvine to Susanville (California) | 4,815.53 mi (7,749.85 km) |
| Irvine to Sussex (Wisconsin) | 3,618.77 mi (5,823.85 km) |
| Irvine to Suwanee (Georgia) | 3,921.86 mi (6,311.63 km) |
| Irvine to Swansea (Illinois) | 3,911.36 mi (6,294.73 km) |
| Irvine to Sweetwater (Florida) | 4,216.58 mi (6,785.94 km) |
| Irvine to Sweetwater (Texas) | 4,609.35 mi (7,418.04 km) |
| Irvine to Sycamore (Illinois) | 3,691.13 mi (5,940.30 km) |
| Irvine to Sylacauga (Alabama) | 4,050.33 mi (6,518.38 km) |
| Irvine to Sylvania (Ohio) | 3,524.27 mi (5,671.77 km) |
| Irvine to Syosset (New York) | 3,183.52 mi (5,123.39 km) |
| Irvine to Syracuse (New York) | 3,179.91 mi (5,117.57 km) |
| Irvine to Syracuse (Utah) | 4,524.05 mi (7,280.76 km) |
