| Irvine to Storm Lake (Iowa) | 3,888.19 mi (6,257.44 km) |
| Irvine to Storrs (Connecticut) | 3,089.33 mi (4,971.80 km) |
| Irvine to Stoughton (Wisconsin) | 3,664.75 mi (5,897.84 km) |
| Irvine to Stow (Ohio) | 3,465.86 mi (5,577.76 km) |
| Irvine to Streamwood (Illinois) | 3,671.76 mi (5,909.12 km) |
| Irvine to Streator (Illinois) | 3,739.65 mi (6,018.38 km) |
| Irvine to Streetsboro (Ohio) | 3,459.51 mi (5,567.54 km) |
| Irvine to Strongsville (Ohio) | 3,474.04 mi (5,590.93 km) |
| Irvine to Stuart (Florida) | 4,135.33 mi (6,655.17 km) |
| Irvine to Stuarts Draft (Virginia) | 3,529.71 mi (5,680.52 km) |
| Irvine to Sturgis (Michigan) | 3,582.59 mi (5,765.62 km) |
| Irvine to Suamico (Wisconsin) | 3,540.67 mi (5,698.16 km) |
| Irvine to Sudley (Virginia) | 3,433.33 mi (5,525.40 km) |
| Irvine to Suffern (New York) | 3,193.93 mi (5,140.13 km) |
| Irvine to Suffolk (Virginia) | 3,503.70 mi (5,638.67 km) |
