| Irvine to Stephenville (Texas) | 4,544.66 mi (7,313.92 km) |
| Irvine to Sterling (Colorado) | 4,264.65 mi (6,863.30 km) |
| Irvine to Sterling (Illinois) | 3,737.17 mi (6,014.40 km) |
| Irvine to Sterling (Virginia) | 3,419.25 mi (5,502.76 km) |
| Irvine to Sterling Heights (Michigan) | 3,457.41 mi (5,564.17 km) |
| Irvine to Steubenville (Ohio) | 3,475.87 mi (5,593.87 km) |
| Irvine to Stevens Point (Wisconsin) | 3,598.29 mi (5,790.88 km) |
| Irvine to Stevenson Ranch (California) | 5,106.64 mi (8,218.34 km) |
| Irvine to Stillwater (Minnesota) | 3,686.22 mi (5,932.41 km) |
| Irvine to Stillwater (Oklahoma) | 4,292.89 mi (6,908.74 km) |
| Irvine to Stockbridge (Georgia) | 3,955.19 mi (6,365.26 km) |
| Irvine to Stockton (California) | 4,978.13 mi (8,011.52 km) |
| Irvine to Stone Ridge (Virginia) | 3,428.69 mi (5,517.94 km) |
| Irvine to Stonecrest (Georgia) | 3,943.44 mi (6,346.36 km) |
| Irvine to Stony Brook (New York) | 3,164.96 mi (5,093.50 km) |
