| Irvine to St. Simons (Georgia) | 3,968.64 mi (6,386.91 km) |
| Irvine to Stafford (Texas) | 4,588.22 mi (7,384.02 km) |
| Irvine to Stallings (North Carolina) | 3,737.67 mi (6,015.21 km) |
| Irvine to Stamford (Connecticut) | 3,172.12 mi (5,105.04 km) |
| Irvine to Stanford (California) | 5,035.18 mi (8,103.34 km) |
| Irvine to Stanton (California) | 5,122.63 mi (8,244.08 km) |
| Irvine to Star (Idaho) | 4,509.38 mi (7,257.15 km) |
| Irvine to Starkville (Mississippi) | 4,132.26 mi (6,650.23 km) |
| Irvine to State College (Pennsylvania) | 3,350.20 mi (5,391.63 km) |
| Irvine to Staten Island (New York) | 3,219.25 mi (5,180.88 km) |
| Irvine to Statesboro (Georgia) | 3,917.87 mi (6,305.20 km) |
| Irvine to Statesville (North Carolina) | 3,711.46 mi (5,973.02 km) |
| Irvine to Staunton (Virginia) | 3,523.75 mi (5,670.92 km) |
| Irvine to Steamboat Springs (Colorado) | 4,391.59 mi (7,067.59 km) |
| Irvine to Steiner Ranch (Texas) | 4,633.62 mi (7,457.09 km) |
