| Irvine to St. George (Utah) | 4,796.43 mi (7,719.10 km) |
| Irvine to St. Helens (Oregon) | 4,560.40 mi (7,339.25 km) |
| Irvine to St. James (New York) | 3,167.30 mi (5,097.27 km) |
| Irvine to St. John (Indiana) | 3,674.68 mi (5,913.82 km) |
| Irvine to St. Joseph (Missouri) | 4,022.72 mi (6,473.94 km) |
| Irvine to St. Louis (Missouri) | 3,916.45 mi (6,302.91 km) |
| Irvine to St. Louis Park (Minnesota) | 3,709.86 mi (5,970.45 km) |
| Irvine to St. Marys (Georgia) | 3,997.91 mi (6,434.01 km) |
| Irvine to St. Marys (Pennsylvania) | 3,343.94 mi (5,381.55 km) |
| Irvine to St. Matthews (Kentucky) | 3,766.62 mi (6,061.80 km) |
| Irvine to St. Michael (Minnesota) | 3,708.59 mi (5,968.40 km) |
| Irvine to St. Paul (Minnesota) | 3,700.96 mi (5,956.13 km) |
| Irvine to St. Peter (Minnesota) | 3,761.13 mi (6,052.96 km) |
| Irvine to St. Peters (Missouri) | 3,922.07 mi (6,311.96 km) |
| Irvine to St. Petersburg (Florida) | 4,197.27 mi (6,754.86 km) |
