| Irvine to Spout Springs (North Carolina) | 3,667.06 mi (5,901.56 km) |
| Irvine to Spring (Texas) | 4,557.87 mi (7,335.18 km) |
| Irvine to Spring Creek (Nevada) | 4,650.43 mi (7,484.14 km) |
| Irvine to Spring Hill (Florida) | 4,155.38 mi (6,687.44 km) |
| Irvine to Spring Hill (Tennessee) | 3,941.73 mi (6,343.60 km) |
| Irvine to Spring Lake (North Carolina) | 3,670.11 mi (5,906.47 km) |
| Irvine to Spring Valley (California) | 5,153.00 mi (8,292.95 km) |
| Irvine to Spring Valley (Nevada) | 4,905.24 mi (7,894.22 km) |
| Irvine to Spring Valley (New York) | 3,190.30 mi (5,134.29 km) |
| Irvine to Springboro (Ohio) | 3,648.96 mi (5,872.44 km) |
| Irvine to Springdale (Arkansas) | 4,185.13 mi (6,735.31 km) |
| Irvine to Springdale (New Jersey) | 3,284.34 mi (5,285.64 km) |
| Irvine to Springdale (Ohio) | 3,671.35 mi (5,908.46 km) |
| Irvine to Springfield (Illinois) | 3,837.35 mi (6,175.61 km) |
| Irvine to Springfield (Massachusetts) | 3,086.13 mi (4,966.64 km) |
