| Irvine to Southern Pines (North Carolina) | 3,685.32 mi (5,930.95 km) |
| Irvine to Southfield (Michigan) | 3,470.85 mi (5,585.80 km) |
| Irvine to Southgate (Michigan) | 3,481.89 mi (5,603.56 km) |
| Irvine to Southlake (Texas) | 4,465.90 mi (7,187.17 km) |
| Irvine to Spanaway (Washington) | 4,478.46 mi (7,207.39 km) |
| Irvine to Spanish Fork (Utah) | 4,565.09 mi (7,346.80 km) |
| Irvine to Spanish Lake (Missouri) | 3,907.31 mi (6,288.20 km) |
| Irvine to Spanish Springs (Nevada) | 4,832.73 mi (7,777.53 km) |
| Irvine to Sparks (Nevada) | 4,838.91 mi (7,787.47 km) |
| Irvine to Spartanburg (South Carolina) | 3,794.37 mi (6,106.45 km) |
| Irvine to Spearfish (South Dakota) | 4,079.96 mi (6,566.06 km) |
| Irvine to Speedway (Indiana) | 3,711.84 mi (5,973.63 km) |
| Irvine to Spencer (Iowa) | 3,861.22 mi (6,214.03 km) |
| Irvine to Spokane (Washington) | 4,313.11 mi (6,941.28 km) |
| Irvine to Spokane Valley (Washington) | 4,307.93 mi (6,932.95 km) |
