| Irvine to Somersworth (New Hampshire) | 2,971.13 mi (4,781.58 km) |
| Irvine to Somerton (Arizona) | 5,088.06 mi (8,188.45 km) |
| Irvine to Somerville (Massachusetts) | 3,018.56 mi (4,857.90 km) |
| Irvine to Somerville (New Jersey) | 3,237.45 mi (5,210.17 km) |
| Irvine to Sonoma (California) | 4,992.65 mi (8,034.89 km) |
| Irvine to Soquel (California) | 5,054.01 mi (8,133.64 km) |
| Irvine to South Bend (Indiana) | 3,619.59 mi (5,825.17 km) |
| Irvine to South Bradenton (Florida) | 4,211.83 mi (6,778.28 km) |
| Irvine to South Burlington (Vermont) | 3,005.40 mi (4,836.73 km) |
| Irvine to South Charleston (West Virginia) | 3,615.15 mi (5,818.03 km) |
| Irvine to South Daytona (Florida) | 4,059.95 mi (6,533.86 km) |
| Irvine to South El Monte (California) | 5,109.84 mi (8,223.49 km) |
| Irvine to South Elgin (Illinois) | 3,678.13 mi (5,919.38 km) |
| Irvine to South Euclid (Ohio) | 3,452.47 mi (5,556.22 km) |
| Irvine to South Farmingdale (New York) | 3,186.06 mi (5,127.47 km) |
