| Irvine to Smyrna (Delaware) | 3,336.71 mi (5,369.92 km) |
| Irvine to Smyrna (Georgia) | 3,948.59 mi (6,354.64 km) |
| Irvine to Smyrna (Tennessee) | 3,915.75 mi (6,301.79 km) |
| Irvine to Snellville (Georgia) | 3,929.46 mi (6,323.86 km) |
| Irvine to Snoqualmie (Washington) | 4,438.53 mi (7,143.13 km) |
| Irvine to Snyder (Texas) | 4,613.88 mi (7,425.32 km) |
| Irvine to Socastee (South Carolina) | 3,746.92 mi (6,030.08 km) |
| Irvine to Socorro (Texas) | 4,860.76 mi (7,822.63 km) |
| Irvine to Soddy-Daisy (Tennessee) | 3,901.52 mi (6,278.88 km) |
| Irvine to Solana Beach (California) | 5,146.57 mi (8,282.60 km) |
| Irvine to Soledad (California) | 5,068.98 mi (8,157.74 km) |
| Irvine to Solon (Ohio) | 3,455.95 mi (5,561.81 km) |
| Irvine to Somers Point (New Jersey) | 3,297.25 mi (5,306.41 km) |
| Irvine to Somerset (Kentucky) | 3,787.15 mi (6,094.83 km) |
| Irvine to Somerset (New Jersey) | 3,236.23 mi (5,208.21 km) |
