| Irvine to Silver Firs (Washington) | 4,427.36 mi (7,125.14 km) |
| Irvine to Silver Spring (Maryland) | 3,404.73 mi (5,479.38 km) |
| Irvine to Silver Springs Shores (Florida) | 4,101.82 mi (6,601.24 km) |
| Irvine to Silverdale (Washington) | 4,452.43 mi (7,165.49 km) |
| Irvine to Silverton (Oregon) | 4,609.00 mi (7,417.46 km) |
| Irvine to Simi Valley (California) | 5,118.73 mi (8,237.81 km) |
| Irvine to Simpsonville (South Carolina) | 3,818.04 mi (6,144.55 km) |
| Irvine to Sioux City (Iowa) | 3,936.76 mi (6,335.60 km) |
| Irvine to Sioux Falls (South Dakota) | 3,895.22 mi (6,268.75 km) |
| Irvine to Skokie (Illinois) | 3,655.24 mi (5,882.54 km) |
| Irvine to Sleepy Hollow (New York) | 3,184.58 mi (5,125.09 km) |
| Irvine to Slidell (Louisiana) | 4,336.29 mi (6,978.59 km) |
| Irvine to Smithfield (North Carolina) | 3,628.64 mi (5,839.73 km) |
| Irvine to Smithfield (Utah) | 4,474.95 mi (7,201.73 km) |
| Irvine to Smithville (Missouri) | 4,033.03 mi (6,490.53 km) |
