| Irvine to Shoreview (Minnesota) | 3,695.35 mi (5,947.09 km) |
| Irvine to Shorewood (Illinois) | 3,697.97 mi (5,951.30 km) |
| Irvine to Shorewood (Wisconsin) | 3,608.86 mi (5,807.90 km) |
| Irvine to Short Hills (New Jersey) | 3,218.69 mi (5,179.98 km) |
| Irvine to Short Pump (Virginia) | 3,493.71 mi (5,622.58 km) |
| Irvine to Show Low (Arizona) | 4,841.04 mi (7,790.91 km) |
| Irvine to Shreveport (Louisiana) | 4,369.62 mi (7,032.23 km) |
| Irvine to Sicklerville (New Jersey) | 3,291.46 mi (5,297.09 km) |
| Irvine to Sidney (Ohio) | 3,610.52 mi (5,810.57 km) |
| Irvine to Sierra Madre (California) | 5,102.95 mi (8,212.41 km) |
| Irvine to Sierra Vista (Arizona) | 5,003.17 mi (8,051.83 km) |
| Irvine to Sierra Vista Southeast (Arizona) | 5,006.11 mi (8,056.55 km) |
| Irvine to Signal Hill (California) | 5,127.87 mi (8,252.51 km) |
| Irvine to Sikeston (Missouri) | 3,982.21 mi (6,408.74 km) |
| Irvine to Siloam Springs (Arkansas) | 4,198.94 mi (6,757.54 km) |
