| Irvine to Shelton (Connecticut) | 3,146.60 mi (5,063.96 km) |
| Irvine to Shelton (Washington) | 4,489.30 mi (7,224.83 km) |
| Irvine to Shenandoah (Louisiana) | 4,376.15 mi (7,042.74 km) |
| Irvine to Shepherdsville (Kentucky) | 3,782.47 mi (6,087.30 km) |
| Irvine to Sheridan (Wyoming) | 4,163.31 mi (6,700.19 km) |
| Irvine to Sherman (Texas) | 4,410.56 mi (7,098.10 km) |
| Irvine to Sherrelwood (Colorado) | 4,366.61 mi (7,027.38 km) |
| Irvine to Sherwood (Arkansas) | 4,184.37 mi (6,734.10 km) |
| Irvine to Sherwood (Oregon) | 4,589.95 mi (7,386.81 km) |
| Irvine to Shiloh (Illinois) | 3,908.68 mi (6,290.42 km) |
| Irvine to Shiloh (Ohio) | 3,636.26 mi (5,851.99 km) |
| Irvine to Shiloh (Pennsylvania) | 3,349.07 mi (5,389.81 km) |
| Irvine to Shirley (New York) | 3,160.57 mi (5,086.44 km) |
| Irvine to Shively (Kentucky) | 3,775.79 mi (6,076.54 km) |
| Irvine to Shoreline (Washington) | 4,438.49 mi (7,143.05 km) |
