| Irvine to Seymour (Tennessee) | 3,816.61 mi (6,142.24 km) |
| Irvine to Shady Hills (Florida) | 4,160.06 mi (6,694.97 km) |
| Irvine to Shafter (California) | 5,061.73 mi (8,146.07 km) |
| Irvine to Shaker Heights (Ohio) | 3,455.79 mi (5,561.56 km) |
| Irvine to Shakopee (Minnesota) | 3,722.32 mi (5,990.49 km) |
| Irvine to Sharon (Pennsylvania) | 3,428.24 mi (5,517.22 km) |
| Irvine to Sharonville (Ohio) | 3,669.21 mi (5,905.02 km) |
| Irvine to Shasta Lake (California) | 4,850.15 mi (7,805.56 km) |
| Irvine to Shawnee (Kansas) | 4,060.76 mi (6,535.16 km) |
| Irvine to Shawnee (Oklahoma) | 4,330.47 mi (6,969.21 km) |
| Irvine to Sheboygan (Wisconsin) | 3,571.84 mi (5,748.32 km) |
| Irvine to Shelby (North Carolina) | 3,762.23 mi (6,054.72 km) |
| Irvine to Shelbyville (Indiana) | 3,707.45 mi (5,966.56 km) |
| Irvine to Shelbyville (Kentucky) | 3,753.57 mi (6,040.78 km) |
| Irvine to Shelbyville (Tennessee) | 3,937.12 mi (6,336.19 km) |
