| Irvine to Security-Widefield (Colorado) | 4,416.13 mi (7,107.07 km) |
| Irvine to Sedalia (Missouri) | 4,020.73 mi (6,470.74 km) |
| Irvine to Sedro-Woolley (Washington) | 4,392.34 mi (7,068.79 km) |
| Irvine to Seguin (Texas) | 4,678.71 mi (7,529.66 km) |
| Irvine to Selden (New York) | 3,163.48 mi (5,091.13 km) |
| Irvine to Selma (Alabama) | 4,119.49 mi (6,629.68 km) |
| Irvine to Selma (California) | 5,010.44 mi (8,063.53 km) |
| Irvine to Selma (Texas) | 4,691.49 mi (7,550.22 km) |
| Irvine to Seminole (Florida) | 4,199.17 mi (6,757.92 km) |
| Irvine to Seven Hills (Ohio) | 3,464.93 mi (5,576.27 km) |
| Irvine to Seven Oaks (South Carolina) | 3,810.44 mi (6,132.31 km) |
| Irvine to Severn (Maryland) | 3,385.88 mi (5,449.05 km) |
| Irvine to Severna Park (Maryland) | 3,383.39 mi (5,445.05 km) |
| Irvine to Sevierville (Tennessee) | 3,808.63 mi (6,129.40 km) |
| Irvine to Seymour (Indiana) | 3,740.94 mi (6,020.47 km) |
