| Irvine to Scottsboro (Alabama) | 3,966.13 mi (6,382.87 km) |
| Irvine to Scottsdale (Arizona) | 4,933.94 mi (7,940.41 km) |
| Irvine to Scranton (Pennsylvania) | 3,238.15 mi (5,211.29 km) |
| Irvine to Seabrook (Maryland) | 3,399.32 mi (5,470.68 km) |
| Irvine to Seabrook (Texas) | 4,570.97 mi (7,356.26 km) |
| Irvine to Seaford (New York) | 3,190.13 mi (5,134.01 km) |
| Irvine to Seagoville (Texas) | 4,460.23 mi (7,178.05 km) |
| Irvine to Seal Beach (California) | 5,127.72 mi (8,252.27 km) |
| Irvine to Searcy (Arkansas) | 4,146.64 mi (6,673.37 km) |
| Irvine to Seaside (California) | 5,072.37 mi (8,163.19 km) |
| Irvine to SeaTac (Washington) | 4,455.28 mi (7,170.09 km) |
| Irvine to Seattle (Washington) | 4,445.79 mi (7,154.81 km) |
| Irvine to Sebastian (Florida) | 4,113.22 mi (6,619.59 km) |
| Irvine to Sebring (Florida) | 4,167.22 mi (6,706.49 km) |
| Irvine to Secaucus (New Jersey) | 3,206.71 mi (5,160.69 km) |
