| Irvine to Savannah (Georgia) | 3,916.35 mi (6,302.75 km) |
| Irvine to Sayreville (New Jersey) | 3,231.49 mi (5,200.57 km) |
| Irvine to Sayville (New York) | 3,170.73 mi (5,102.80 km) |
| Irvine to Scaggsville (Maryland) | 3,392.78 mi (5,460.15 km) |
| Irvine to Scarsdale (New York) | 3,185.82 mi (5,127.08 km) |
| Irvine to Schaumburg (Illinois) | 3,667.88 mi (5,902.89 km) |
| Irvine to Schenectady (New York) | 3,107.26 mi (5,000.66 km) |
| Irvine to Schererville (Indiana) | 3,671.62 mi (5,908.90 km) |
| Irvine to Schertz (Texas) | 4,690.49 mi (7,548.62 km) |
| Irvine to Schiller Park (Illinois) | 3,663.71 mi (5,896.17 km) |
| Irvine to Schofield Barracks (Hawaii) | 6,884.25 mi (11,079.13 km) |
| Irvine to Scotchtown (New York) | 3,185.45 mi (5,126.49 km) |
| Irvine to Scottdale (Georgia) | 3,942.50 mi (6,344.84 km) |
| Irvine to Scotts Valley (California) | 5,052.45 mi (8,131.13 km) |
| Irvine to Scottsbluff (Nebraska) | 4,213.61 mi (6,781.15 km) |
