| Irvine to Santa Rosa (California) | 4,990.50 mi (8,031.43 km) |
| Irvine to Santaquin (Utah) | 4,577.66 mi (7,367.02 km) |
| Irvine to Santee (California) | 5,146.08 mi (8,281.82 km) |
| Irvine to Sapulpa (Oklahoma) | 4,264.61 mi (6,863.23 km) |
| Irvine to Saraland (Alabama) | 4,242.83 mi (6,828.18 km) |
| Irvine to Sarasota (Florida) | 4,216.88 mi (6,786.41 km) |
| Irvine to Sarasota Springs (Florida) | 4,215.83 mi (6,784.72 km) |
| Irvine to Saratoga (California) | 5,040.34 mi (8,111.65 km) |
| Irvine to Saratoga Springs (New York) | 3,089.45 mi (4,971.98 km) |
| Irvine to Saratoga Springs (Utah) | 4,560.56 mi (7,339.51 km) |
| Irvine to Sartell (Minnesota) | 3,706.00 mi (5,964.23 km) |
| Irvine to Satellite Beach (Florida) | 4,096.77 mi (6,593.11 km) |
| Irvine to Sauk Rapids (Minnesota) | 3,704.75 mi (5,962.23 km) |
| Irvine to Sault Ste. Marie (Michigan) | 3,322.87 mi (5,347.65 km) |
| Irvine to Savage (Minnesota) | 3,719.39 mi (5,985.79 km) |
