| Irvine to Sanford (Maine) | 2,958.54 mi (4,761.32 km) |
| Irvine to Sanford (North Carolina) | 3,661.69 mi (5,892.93 km) |
| Irvine to Sanger (California) | 5,001.32 mi (8,048.85 km) |
| Irvine to Santa Ana (California) | 5,122.87 mi (8,244.47 km) |
| Irvine to Santa Barbara (California) | 5,138.82 mi (8,270.13 km) |
| Irvine to Santa Clara (California) | 5,033.00 mi (8,099.84 km) |
| Irvine to Santa Clara (Oregon) | 4,670.02 mi (7,515.68 km) |
| Irvine to Santa Clarita (California) | 5,102.18 mi (8,211.17 km) |
| Irvine to Santa Cruz (California) | 5,057.62 mi (8,139.45 km) |
| Irvine to Santa Fe (New Mexico) | 4,627.67 mi (7,447.51 km) |
| Irvine to Santa Fe (Texas) | 4,583.94 mi (7,377.14 km) |
| Irvine to Santa Fe Springs (California) | 5,117.05 mi (8,235.09 km) |
| Irvine to Santa Maria (California) | 5,130.99 mi (8,257.54 km) |
| Irvine to Santa Monica (California) | 5,124.67 mi (8,247.36 km) |
| Irvine to Santa Paula (California) | 5,123.26 mi (8,245.09 km) |
