| Irvine to Saddlebrooke (Arizona) | 4,965.39 mi (7,991.03 km) |
| Irvine to Safety Harbor (Florida) | 4,186.99 mi (6,738.31 km) |
| Irvine to Saginaw (Michigan) | 3,450.99 mi (5,553.82 km) |
| Irvine to Saginaw (Texas) | 4,478.48 mi (7,207.41 km) |
| Irvine to Sahuarita (Arizona) | 5,003.95 mi (8,053.08 km) |
| Irvine to Saks (Alabama) | 4,007.11 mi (6,448.81 km) |
| Irvine to Salem (Massachusetts) | 3,005.36 mi (4,836.65 km) |
| Irvine to Salem (Ohio) | 3,457.14 mi (5,563.73 km) |
| Irvine to Salem (Oregon) | 4,620.07 mi (7,435.29 km) |
| Irvine to Salem (Virginia) | 3,604.88 mi (5,801.49 km) |
| Irvine to Salem Lakes (Wisconsin) | 3,644.72 mi (5,865.61 km) |
| Irvine to Salida (California) | 4,987.26 mi (8,026.23 km) |
| Irvine to Salina (Kansas) | 4,170.10 mi (6,711.13 km) |
| Irvine to Salinas (California) | 5,063.02 mi (8,148.14 km) |
| Irvine to Salisbury (Maryland) | 3,380.45 mi (5,440.30 km) |
