| Irvine to Reidsville (North Carolina) | 3,637.80 mi (5,854.47 km) |
| Irvine to Reisterstown (Maryland) | 3,374.91 mi (5,431.39 km) |
| Irvine to Rendon (Texas) | 4,489.25 mi (7,224.76 km) |
| Irvine to Reno (Nevada) | 4,844.12 mi (7,795.86 km) |
| Irvine to Renton (Washington) | 4,450.56 mi (7,162.49 km) |
| Irvine to Republic (Missouri) | 4,109.33 mi (6,613.33 km) |
| Irvine to Reston (Virginia) | 3,419.71 mi (5,503.50 km) |
| Irvine to Revere (Massachusetts) | 3,013.55 mi (4,849.83 km) |
| Irvine to Rexburg (Idaho) | 4,364.08 mi (7,023.31 km) |
| Irvine to Reynoldsburg (Ohio) | 3,575.78 mi (5,754.67 km) |
| Irvine to Rialto (California) | 5,085.46 mi (8,184.26 km) |
| Irvine to Richardson (Texas) | 4,449.00 mi (7,159.97 km) |
| Irvine to Richfield (Minnesota) | 3,710.63 mi (5,971.68 km) |
| Irvine to Richfield (Wisconsin) | 3,614.44 mi (5,816.88 km) |
| Irvine to Richland (Washington) | 4,441.89 mi (7,148.54 km) |
